Progressive Supranuclear Palsy

A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

Also Known As:

Steele Richardson Olszewski Syndrome; Progressive Supranuclear Ophthalmoplegia; Supranuclear Palsy, Progressive; Palsy, Progressive Supranuclear; Richardson's Syndrome; Steele-Richardson-Olszewski Disease; Supranuclear Palsy, Progressive, 1; Progressive Supranuclear Palsies; Richardson Syndrome; Steele Richardson Olszewski Disease; Supranuclear Ophthalmoplegia, Progressive; Supranuclear Palsies, Progressive; Ophthalmoplegia, Progressive Supranuclear; Progressive Supranuclear Palsy 1; Steele-Richardson-Olszewski Syndrome

Nervous System Diseases: 14737
- Neurodegenerative Diseases: 44095
  - Tauopathies: 2958
    - Progressive Supranuclear Palsy: 1268
- Neurologic Manifestations: 7223
  - Paralysis: 14443
    - Ophthalmoplegia: 893
      - Progressive Supranuclear Palsy: 1268
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Basal Ganglia Diseases: 350
      - Progressive Supranuclear Palsy: 1268
  - Movement Disorders: 4780
    - Progressive Supranuclear Palsy: 1268
- Cranial Nerve Diseases: 564
  - Ocular Motility Disorders: 523
    - Ophthalmoplegia: 893
      - Progressive Supranuclear Palsy: 1268
Eye Diseases: 3620
- Ocular Motility Disorders: 523
  - Ophthalmoplegia: 893
    - Progressive Supranuclear Palsy: 1268
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7223
    - Paralysis: 14443
      - Ophthalmoplegia: 893
        Progressive Supranuclear Palsy: 1268

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